| 标题： | 中国人群结直肠癌风险管理公众指南 |
| title： | Chinese Guideline on Risk Management of Colorectal Cancer in the General Public |
| 版本： | 原创版 |
| version： | Original |
| 分类： | 标准指南 |
| classification： | Standard guideline |
| 领域： | 综合 |
| field： | Comprehensive guideline |
| 国家和地区： | 中国 |
| Country and region： | China |
| 指南使用者： | 全国各地、各民族的健康人群，结直肠癌的高危人群 |
| Guide users： | The guideline is intended for the general population, encompassing individuals from various ethnicities and regions nationwide, as well as those at high risk for colorectal cancer. |
| 证据分级方法： | 采用GRADE方法对结直肠癌发生风险相关的证据进行质量评价。根据GRADE方法，证据质量分为高、中、低、极低四个等级。在证据分级过程中，有五个降级因素：局限性、不确定性、不一致性、不直接性以及发表偏倚；有三个升级因素：效应量大、剂量反应关系以及可能的混杂因素（负偏移）。 |
| Evidence grading method： | Using the GRADE method, evidence related to the risk of colorectal cancer occurrence is assessed for quality. According to the GRADE method, the quality of evidence is categorized into four levels: high, moderate, low, and very low. During the process of grading the evidence, there are five factors for downgrading: limitations, uncertainty, inconsistency, indirectness, and publication bias; and three factors for upgrading: a large effect size, a dose-response relationship, and the potential for confounding factors (negative confounding). |
| 制定单位： | 中国人群健康风险管理协作组-结直肠癌专业组 |
| Formulating unit： | Chinese Health RIsk MAnagement Collaboration (CHRIMAC) |
| 注册时间： | 2023-12-11 |
| Registration time： | |
| 注册编号： | PREPARE-2023CN160 |
| Registration number： | |
| 指南制订的目的： | 结直肠癌是我国常见的恶性肿瘤之一，发病率、死亡率在所有恶性肿瘤中均位居前列，给社会带来极重的疾病负担。从数据来看，我国结直肠癌发病率呈从上世纪80年代2.75/10万人已上升到2020年的19.39/10万，城市地区相对农村更易高发，男性略高于女性。大量流行病学研究表明：久坐不动、高盐高脂饮食、吸烟等不良生活习惯与结直肠癌的关联性显著。因此，本指南将针对结直肠癌的危险因素进行梳理并就相关证据进行系统评价，总结形成结直肠癌风险管理公众指南，从而指导结直肠癌的疾病预防。 |
| Purpose of the guideline： | Colorectal cancer is one of the common malignant tumors in China, with incidence and mortality rates consistently ranking high among all malignancies. The disease burden it imposes on society is substantial. From a data perspective, the incidence rate of colorectal cancer in China has risen from 2.75 per 100,000 people in the 1980s to 19.39 per 100,000 in 2020. Urban areas exhibit a higher incidence compared to rural areas, and the disease is slightly more prevalent in males than females.Extensive epidemiological studies suggest a significant association between sedentary lifestyles, high-salt and high-fat diets, smoking, and the development of colorectal cancer. Therefore, this guideline aims to systematically review the risk factors associated with colorectal cancer and conduct evidence-based evaluations. The objective is to formulate a public guideline for colorectal cancer risk management, providing guidance on disease prevention. |
