| Title： | Chinese Guideline on Risk Management of Colorectal Cancer in the General Public |
| Edition： | Original |
| Classification： | Standard guideline |
| Field： | Comprehensive guideline |
| Countries and regions： | China |
| Guidelines users： | The guideline is intended for the general population, encompassing individuals from various ethnicities and regions nationwide, as well as those at high risk for colorectal cancer. |
| Evidence classification method： | Using the GRADE method, evidence related to the risk of colorectal cancer occurrence is assessed for quality. According to the GRADE method, the quality of evidence is categorized into four levels: high, moderate, low, and very low. During the process of grading the evidence, there are five factors for downgrading: limitations, uncertainty, inconsistency, indirectness, and publication bias; and three factors for upgrading: a large effect size, a dose-response relationship, and the potential for confounding factors (negative confounding). |
| Development unit： | Chinese Health RIsk MAnagement Collaboration (CHRIMAC) |
| Registration time: | 2023-12-11 |
| Registration number： | PREPARE-2023CN160 |
| Purpose of the guideline: | Colorectal cancer is one of the common malignant tumors in China, with incidence and mortality rates consistently ranking high among all malignancies. The disease burden it imposes on society is substantial. From a data perspective, the incidence rate of colorectal cancer in China has risen from 2.75 per 100,000 people in the 1980s to 19.39 per 100,000 in 2020. Urban areas exhibit a higher incidence compared to rural areas, and the disease is slightly more prevalent in males than females.Extensive epidemiological studies suggest a significant association between sedentary lifestyles, high-salt and high-fat diets, smoking, and the development of colorectal cancer. Therefore, this guideline aims to systematically review the risk factors associated with colorectal cancer and conduct evidence-based evaluations. The objective is to formulate a public guideline for colorectal cancer risk management, providing guidance on disease prevention. |
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