| 标题： | 中国人群胆结石风险管理公众指南 |
| title： | Chinese Guideline on Risk Management of Gallstone Disease in the General Public |
| 版本： | 原创版 |
| version： | Original |
| 分类： | 标准指南 |
| classification： | Standard guideline |
| 领域： | 预防 |
| field： | Prevention |
| 国家和地区： | 中国 |
| Country and region： | China |
| 指南使用者： | 全国各地、各民族的健康人群和胆结石高风险人群。 |
| Guide users： | Healthy individuals and high-risk populations for gallstones across different regions and ethnicities nationwide. |
| 证据分级方法： | 对本指南纳入的证据采用GRADE方法进行质量评价，根据GRADE方法，将证据质量分为高、中、低、极低四个等级。在证据分级过程中，存在五个降级因素：局限性、不精确性、不一致性、不直接性以及发表偏倚和三个升级因素：效应量大、剂量反应关系和可能的混杂因素（负偏倚）。 |
| Evidence grading method： | The evidence included in this guideline is assessed for quality using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach, which categorizes evidence quality into four levels: high, moderate, low, and very low. During the process of grading the evidence, there are five factors for downgrading: limitations, imprecision, inconsistency, indirectness, and publication bias, and three factors for upgrading: large effect size, dose-response relationship, and possible confounding factors (negative bias). |
| 制定单位： | 中国人群健康风险管理协作组-胆结石专业组 |
| Formulating unit： | Chinese Health RIsk MAnagement Collaboration (CHRIMAC)-Gallstone Disease Group |
| 注册时间： | 2023-11-27 |
| Registration time： | |
| 注册编号： | PREPARE-2023CN968 |
| Registration number： | |
| 指南制订的目的： | 胆结石是指胆道系统包括胆囊或胆管内发生结石的疾病，我国的成人发病率约为10%-15%，男女发病率比约为1：1.25，且近年来呈现上升趋势。胆结石不仅会引起急性胆囊炎、胆管炎等急性疾病，还可能诱发慢性胆囊炎、慢性胰腺炎等慢性疾病，并增加胆囊癌的发生风险。由于发病率高、疾病负担重，胆结石已经成为重要的临床及公共卫生问题。因此，制定和实施胆结石风险管理的公众指南对于预防、早期诊断和治疗胆结石具有重要意义。这些指南通常包括胆结石风险因素的评估、生活方式改变、饮食建议、医学手段干预等多方面内容，旨在降低胆结石的发病率、减少相关并发症的发生，以及提高公众对胆结石预防和管理的认知水平。 |
| Purpose of the guideline： | Gallstone disease is one of the most common gastrointestinal disorders. The prevalence of cholelithiasis worldwide ranges from 10% to 20%, with a male-to-female ratio of about 1:1.25, and has shown an increasing trend in recent years. Gallstones not only lead to acute conditions like acute cholecystitis or cholangitis but can also trigger chronic diseases such as chronic cholecystitis, chronic pancreatitis, and elevate the risk of gallbladder cancer. Due to its high prevalence and substantial disease burden, gallstones have become a significant clinical and public health issue. Therefore, developing and implementing public guidelines for managing gallstone risks holds significant importance in preventing, early diagnosis, and treating gallstones. These guidelines typically encompass various aspects, including assessing gallstone risk factors, lifestyle modifications, dietary advice, medical interventions, and aim to reduce the incidence of gallstones, minimize related complications, and enhance public awareness regarding gallstone prevention and management. |
