| 标题： | 儿童耐大环内酯类抗菌药物肺炎支原体（MRMP）感染诊断与治疗的中国专家共识 |
| title： | Chinese expert concensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae (MRMP) infections in children |
| 版本： | 原创版 |
| version： | Original |
| 分类： | 专家共识 |
| classification： | Experts consensus |
| 领域： | 诊疗 |
| field： | Diagnosis and Treatment |
| 国家和地区： | 中国 |
| Country and region： | China |
| 指南使用者： | 儿科医生 |
| Guide users： | Pediatricians |
| 证据分级方法： | 本专家共识未采用基于系统评价证据分级方法，而采取2轮德尔菲专家函询对关键临床问题达成共识，在此基础上通过一轮函询对推荐意见达成共识。 |
| Evidence grading method： | We did not use the rating system for the hierarchy of evidence. Actually, we conducted two rounds of Delphi methods to archive consensus on the key clinical questions, and one round of online voting to make agreements on recommendation options of each clinical question. |
| 制定单位： | 国家儿童健康与疾病临床医学研究中心，浙江大学医学院附属儿童医院 |
| Formulating unit： | National Clinical Research Center for Child Health, Children’s Hospital, Zhejiang University School of Medicine |
| 注册时间： | 2024-04-19 |
| Registration time： | |
| 注册编号： | PREPARE-2024CN543 |
| Registration number： | |
| 指南制订的目的： | 肺炎支原体是儿童社区获得性肺炎的重要诱因。自1968年日本首次报道对大环内酯类抗生素具有耐药性的肺炎支原体菌株以来，世界各地的许多国家都记录了耐大环内酯类抗菌药物肺炎支原体（MRMP），其发病率各不相同。MRMP感染可能会导致对大环内酯类抗生素的反应不佳，经常导致发烧时间延长、抗生素治疗持续时间延长、住院和重症监护室（ICU）入院人数增加，以及接受糖皮质激素或二线抗生素的患者比例明显更高。自2000年以来，MRMP的全球发病率逐渐上升，尤其是在东亚，这对儿童肺炎支原体感染的治疗提出了严重挑战，并引起了儿科医生的广泛关注。但到目前为止，对MRMP的诊断和治疗仍缺乏共识。为了指导儿科医生更好地解决这一问题，我们组织了29位中国专家，在收集证据的基础上，撰写了关于儿童MRMP诊断和治疗的共识，希望为临床实践提供科学指导。 |
| Purpose of the guideline： | Mycoplasma pneumoniae (M. pneumoniae) is a significant contributor to community-acquired pneumonia (CAP) among children. Since 1968, when a strain of M. pneumoniae resistant to macrolide antibiotics was initially reported in Japan, Macrolide-resistant M. pneumoniae (MRMP) has been documented in many countries worldwide, with different incidences. MRMP infection might cause a poor response to macrolide antibiotics, frequently resulting in prolonged fever, longer duration of antibiotic treatment, increased hospitalization, and intensive care unit (ICU) admission, and a significantly higher proportion of patients receiving glucocorticoids or second-line antibiotics. Since 2000, the global incidence of MRMP has gradually increased, especially in East Asia, which has posed a serious challenge to the treatment of M. pneumoniae infections in children and attracted widespread attention from pediatricians. But so far, there is still a lack of consensus on the diagnosis and treatment of MRMP in children worldwide. To guide pediatricians in better addressing this issue, we organized 29 Chinese experts majoring in pediatric pulmonology to write the consensus on the diagnosis and treatment of pediatric MRMP based on evidence collection, hoping to provide scientific guidance for clinical practice. |
最新注册
