| Title： | Chinese expert concensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae (MRMP) infections in children |
| Edition： | Original |
| Classification： | Experts consensus |
| Field： | Diagnosis and Treatment |
| Countries and regions： | China |
| Guidelines users： | Pediatricians |
| Evidence classification method： | We did not use the rating system for the hierarchy of evidence. Actually, we conducted two rounds of Delphi methods to archive consensus on the key clinical questions, and one round of online voting to make agreements on recommendation options of each clinical question. |
| Development unit： | National Clinical Research Center for Child Health, Children’s Hospital, Zhejiang University School of Medicine |
| Registration time: | 2024-04-19 |
| Registration number： | PREPARE-2024CN543 |
| Purpose of the guideline: | Mycoplasma pneumoniae (M. pneumoniae) is a significant contributor to community-acquired pneumonia (CAP) among children. Since 1968, when a strain of M. pneumoniae resistant to macrolide antibiotics was initially reported in Japan, Macrolide-resistant M. pneumoniae (MRMP) has been documented in many countries worldwide, with different incidences. MRMP infection might cause a poor response to macrolide antibiotics, frequently resulting in prolonged fever, longer duration of antibiotic treatment, increased hospitalization, and intensive care unit (ICU) admission, and a significantly higher proportion of patients receiving glucocorticoids or second-line antibiotics. Since 2000, the global incidence of MRMP has gradually increased, especially in East Asia, which has posed a serious challenge to the treatment of M. pneumoniae infections in children and attracted widespread attention from pediatricians. But so far, there is still a lack of consensus on the diagnosis and treatment of MRMP in children worldwide. To guide pediatricians in better addressing this issue, we organized 29 Chinese experts majoring in pediatric pulmonology to write the consensus on the diagnosis and treatment of pediatric MRMP based on evidence collection, hoping to provide scientific guidance for clinical practice. |
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