| 标题： | 中国人群认知能力下降及痴呆风险管理公众指南 |
| title： | Chinese Guideline on Risk Management of Cognitive Decline and Dementia in the General Public |
| 版本： | 原创版 |
| version： | Original |
| 分类： | 标准指南 |
| classification： | Standard guideline |
| 领域： | 预防 |
| field： | Prevention |
| 国家和地区： | 中国 |
| Country and region： | China |
| 指南使用者： | 全国各地，各民族的健康人群和认知能力下降以及痴呆高风险人群。 |
| Guide users： | The target audience of this guideline is the general population in all regions and all ethnic groups of China, especially adults at high risk of cognitive decline and dementia. |
| 证据分级方法： | 对认知能力下降及痴呆证据体采用GRADE方法进行质量评价。根据GRADE方法，将证据质量分为高、中、低、极低四个等级。在证据分级过程中，存在五个降级因素：局限性、不精确性、不一致性、不直接性以及发表偏倚和三个升级因素：效应量大、剂量反应关系以及可能的混杂因素(负偏倚)。 |
| Evidence grading method： | The GRADE method will be used to evaluate the quality of evidence related to cognitive decline and dementia. According to the GRADE method, the quality of evidence will be divided into high quality, moderate quality, low quality, and very low quality. In the evidence grading process, there are five downgrading factors: limitations, imprecision, inconsistency, indirectness, and publication bias, and three upgrading factors: large effect size, dose-response relationship, and possible confounders (negative bias). |
| 制定单位： | 中国人群健康风险管理协作组‑痴呆专业组 |
| Formulating unit： | Chinese Health RIsk MAnagement Collaboration (CHRIMAC)‑Dementia Group |
| 注册时间： | 2023-11-27 |
| Registration time： | |
| 注册编号： | PREPARE-2023CN960 |
| Registration number： | |
| 指南制订的目的： | 认知能力下降及痴呆是当前日益严峻的公共卫生问题，严重影响患者及患者家属的生活质量，给患者家庭及社会造成沉重的经济负担。痴呆的临床治疗收效甚微，但是主动预防可改变的危险因素可以有效地延迟或减缓疾病的发病或进展。本指南是对健康人群以及高风险人群预防认知能力下降及痴呆的相关证据进行系统的梳理总结，并形成风险管理公众指南，从而指导认知能力下降及痴呆的疾病预防与控制。 |
| Purpose of the guideline： | Cognitive decline and dementia is a current public health problem that seriously affects the quality of life, and imposes a heavy economic burden on patients' families and society. The clinical treatment effect of dementia is minimal, but changing the modifiable risk factors can effectively prevent the disease. This guideline systematically reviews and summarizes relevant evidence on the prevention of dementia and cognitive decline in the general population and high-risk groups, and forms a public guide for risk management, thereby guiding the prevention and control of cognitive decline and dementia. |
