| Title： | KSUMC Evidenced-Based Clinical Practice Guideline for Management of Sedation and Analgesia in Pediatric Intensive Care Unit |
| Edition： | Adapted |
| Classification： | Standard guideline |
| Field： | Comprehensive guideline |
| Countries and regions： | Saudi Arabia |
| Guidelines users： | All Physicians, clinical pharmacists, pharmacists, nurses working in the PICU. |
| Evidence classification method： | The description of the methodology for the production of this adapted CPG can be fulfilled by utilizing the King Saud University (KSU) Modified ADAPTE method. This CPG formal adaptation method included three phases (setup, adaptation, and finalization), nine modules, and 24 steps with modifications in the steps and tools to suit the local general healthcare setting in Saudi Arabia. Overall, the steps of CPG adaptation included the selection of the health topic, formulation of the CPG adaptation working group, identification of health questions using the PIPOH model, searching and selecting Source CPGs with clear inclusion and exclusion criteria, quality assessment of included Source CPGs by using the Appraisal of Guidelines for Research and Evaluation (AGREE) II Instrument, assessment of the currency of the selected Source CPG, drafting of the adapted CPG, external review and consultation process, finalization of the adapted CPG with a set of implementation tools, declaration of conflicts of interests, and finally a plan for review and update. For further details on the specific modifications in steps and tools, refer to the article by Amer et al. 2019 (https://doi.org/10.1111/jep.12927). |
| Development unit： | King Saud University Medical City (KSUMC) |
| Registration time: | 2022-08-18 |
| Registration number： | PREPARE-2022CN527 |
| Purpose of the guideline: | To implement validated scores for assessment of adequacy of sedation/analgesia (Comfort B score) and for assessment of withdrawal symptoms (WAT 1). To develop standardized algorithms to manage sedation/analgesia in PICU patients aiming to: Decrease in population exposure to opioids and benzodiazepines. Decrease in duration on mechanical ventilation. Decrease in PICU length of stay. Improve interdisciplinary communication between clinical pharmacist and health care professionals at all stages. To standardize the therapeutic use of sedation and analgesia that include assessment, selection of agents, adjustment of dosage regimens, weaning plans and management of withdrawal symptoms. |
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