中国遗传性视网膜疾病基因治疗围手术期管理专家共识

标题: 中国遗传性视网膜疾病基因治疗围手术期管理专家共识
title: Expert consensus on the perioperative management of gene therapy for inherited retinal diseases in China
版本: 原创版
version: Original
分类: 专家共识
classification: Experts consensus
领域: 治疗
field: Treatment
国家和地区: 中国
Country and region: China
指南使用者:
Guide users:
证据分级方法: 不适用
Evidence grading method: Not Applicable
制定单位: 中华医学会眼科学分会眼底病学组 中国医师协会眼科医师分会眼底病专业委员会
Formulating unit: Fundus Disease Group of Ophthalmology Society of Chinese Medical Association, and Fundus Disease committee of Ophthalmology Society Chinese Medical Doctor Association
注册时间: 2022-06-18
Registration time:
注册编号: IPGRP-2022CN348
Registration number:
指南制订的目的: 遗传性视网膜疾病(IRDs)是一组严重的视网膜退行性疾病,可造成严重永久性视功能损害,是儿童及工作年龄人群不可逆盲重要病因。基因治疗是临床上全新治疗手段,同时也是IRDs目前唯一明确有效的治疗手段,但其在临床研究和应用中仍存在风险,如何在围手术期进行规范管理,降低治疗的潜在风险是保障治疗安全有效的关键措施之一。目前针对IRDs基因治疗的围手术期管理尚未形成系统的规范化指导意见。因此,为了规范IRDs基因治疗的围手术期管理,中华医学会眼科学分会眼底病学组及中国医师协会眼科医师分会眼底病专业委员会组织国内相关专家,结合国内外研究经验,经过反复讨论,提出了我国IRDs基因治疗的围手术期管理的规范化意见,以供临床医师在临床研究和实践中参考应用。
Purpose of the guideline: Inherited retinal diseases (IRDs) are a group of severe retinal degenerative diseases leading to permanent visual impairment. IRDs are the major cause of irreversible blindness in children and working age groups. Gene therapy is a new clinical treatment method and currently the only clear and effective treatment for IRDs. while, there are still risks in clinical research and application. How to standardize perioperative management and reduce the potential risks of treatment is one of the keys to ensure the safety and effectiveness of treatment. However, there is no systematic and standardized guidance on the perioperative management for IRDs gene therapy. Therefore, in order to standardize the perioperative management, the Fundus Disease Group of Ophthalmology Society of Chinese Medical Association and Chinese Medical Doctor Association organized domestic experts to put forward standardized opinions on the perioperative management of IRDs gene therapy in China after repeated discussion and combined with domestic and foreign research experience, so as to provide clinicians with reference and application in clinical research and practice.